ZnT-8 rabbit pAb
ENT-A5050
Description
| REF | ENT-A5050 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ZnT-8 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC30A8. AA range:171-220 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 41kD |
| Human Gene ID | 169026 |
| Human Swiss Prot Nº | Q8IWU4 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Associated with insulin and glucagon secretory granules. . |
Other Name: SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8
Background: The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],