VE-Cadherin rabbit pAb
ENT-A4452
Description
| REF | ENT-A4452 |
|---|---|
| Category | Antibody Polyclonal |
| Description | VE-Cadherin rabbit pAb |
| Source | Rabbit |
| Applications | IF;WB;IHC;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CDH5. AA range:391-440 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 86kD |
| Human Gene ID | 1003 |
| Human Swiss Prot Nº | P33151 |
| Subcellular Location | Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. . |
Other Name: CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD144
Background: This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],