Tyk2 (phospho-Tyr1054/1055) rabbit pAb
ENT-A11545
Description
| REF | ENT-A11545 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Tyk2 (phospho-Tyr1054/1055) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 134kD |
| Human Gene ID | 7297 |
| Human Swiss Prot Nº | P29597 |
| Subcellular Location | nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome, |
Other Name: Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Background: tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) – a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],