Tuberin (phospho Thr1462) rabbit pAb
ENT-A7173
Description
| REF | ENT-A7173 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Tuberin (phospho Thr1462) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Immunohistochemistry: 1/100 – 1/300. Immunofluorescence: 1/200 – 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Thr1462. AA range:1428-1477 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 200kD |
| Human Gene ID | 7249 |
| Human Swiss Prot Nº | P49815 |
| Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes. |
Other Name: TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein
Background: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],