TPR rabbit pAb
ENT-A11621
Description
| REF | ENT-A11621 |
|---|---|
| Category | Antibody Polyclonal |
| Description | TPR rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1：500-2000 |
| Immunogen | Synthesized peptide derived from human TPR AA range: 2191-2241 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 7175 |
| Human Swiss Prot Nº | P12270 |
| Subcellular Location | Nucleus . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Nucleus envelope . Nucleus, nuclear pore complex . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures a |
Other Name:
Background: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5′ end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008],