Stat4 (phospho Tyr693) rabbit pAb
ENT-A1914
Description
| REF | ENT-A1914 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Stat4 (phospho Tyr693) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;IP;ELISA |
| Reactivity | Human;Mouse;Rat;Monkey |
| Reactivity | Human;Mouse;Rat;Monkey |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STAT4 around the phosphorylation site of Tyr693. AA range:660-709 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 86kD |
| Human Gene ID | 6775 |
| Human Swiss Prot Nº | Q14765 |
| Subcellular Location | Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
Other Name: STAT4; Signal transducer and activator of transcription 4
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011],