SPTN2 rabbit pAb
ENT-A11861
Description
| REF | ENT-A11861 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SPTN2 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Rat |
| Reactivity | Human;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human SPTN2 AA range: 644-694 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 6712 |
| Human Swiss Prot Nº | O15020 |
| Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. |
Other Name:
Background: Spectrins are principle components of a cell’s membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],