Spectrin β II rabbit pAb
ENT-A7015
Description
| REF | ENT-A7015 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Spectrin β II rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SPTBN1. AA range:651-700 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 275kD |
| Human Gene ID | 6711 |
| Human Swiss Prot Nº | Q01082 |
| Subcellular Location | Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, M line . Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. .; [Isoform 2]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . |
Other Name: SPTBN1; SPTB2; Spectrin beta chain; non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],