Sox2 (phospho-Ser250/Ser251) rabbit pAb
ENT-A11894
Description
| REF | ENT-A11894 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Sox2 (phospho-Ser250/Ser251) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized phosho peptide around human Sox2 (Ser250 and Ser251) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 35kD |
| Human Gene ID | 6657 |
| Human Swiss Prot Nº | P48431 |
| Subcellular Location | Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). . |
Other Name: Transcription factor SOX-2
Background: SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],