SOD1 rabbit pAb
ENT-A15954
Description
| REF | ENT-A15954 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SOD1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000.IHC-p:1:50-300. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from the Internal region of human SOD-1. |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | |
| Observed Band KD | 18kD |
| Human Gene ID | 6647 |
| Human Swiss Prot Nº | P00441 |
| Subcellular Location | Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. . |
Other Name: SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
Background: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008],