Smad3 (4C9) Mouse mAb
ENT-A1596
Description
| Ref | ENT-A1596 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | hMAD3 antibody, HSPC193 antibody, LDS1C antibody, MADH3 antibody, JV15 2 antibody |
| Application | WB, IHC |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | WB 1:1,000-2,000 IHC 1:100-200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 52kDa |
| Human Gene ID | 4088 |
| Human Swiss Prot No | P84022 |
| Subcellular Location | Cytoplasm, Nucleus |
Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription.