SETMAR rabbit pAb
ENT-A6921
Description
| REF | ENT-A6921 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SETMAR rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SETMAR. AA range:350-400 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 6419 |
| Human Swiss Prot Nº | Q53H47 |
| Subcellular Location | Nucleus . Chromosome . Recruited on damaged DNA at sites of double-strand breaks. . |
Other Name: SETMAR; Histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion gene-containing protein; HsMar1; Metnase
Background: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],