SC6A4 rabbit pAb
ENT-A12021
Description
| REF | ENT-A12021 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SC6A4 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. Immunofluorescence: 1/200 – 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human SC6A4 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 69kD |
| Human Gene ID | 6532 |
| Human Swiss Prot Nº | P31645 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Endomembrane system ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell junction, focal adhesion . Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). . |
Other Name: Sodium-dependent serotonin transporter (5HT transporter;5HTT;Solute carrier family 6 member 4)
Background: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008],