RPGF4 rabbit pAb
ENT-A9386
Description
| REF | ENT-A9386 |
|---|---|
| Category | Antibody Polyclonal |
| Description | RPGF4 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Rat;Mouse |
| Reactivity | Human;Rat;Mouse |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 240-320 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 111kD |
| Human Gene ID | 11069 |
| Human Swiss Prot Nº | Q8WZA2 |
| Subcellular Location | Cytoplasm. Membrane ; Peripheral membrane protein . |
Other Name:
Background: domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,domain:The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.,function:Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,subunit:Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.,tissue specificity:Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.,