Recombinant Mouse TGFBR2 (C-6His)
Recombinant Mouse Transforming Growth Factor-beta RecESCItor Type II is produced by our Mammalian expression system and the target gene encoding Ile24-Asp159 is expressed with a 6His tag at the C-terminus.
Description
| Reference | ESCIT293 |
|---|---|
| Size | 50ug |
| Molecular Weight | 16.2 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity | Measured by its ability to inhibit TGF-beta 1 activity on TF?1 human erythroleukemic cells.The ED50 for this effect is 1680.39ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1. |
Other names: TGF-beta recESCItor type-2; TGFR-2; TGF-beta type II recESCItor; Transforming growth factor-beta recESCItor type II; TGF-beta recESCItor type II; TbetaR-II; Tgfbr2
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: Transforming growth factor-? (TGF-?) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix dESCIosition. TGF-? regulates cellular processes by binding to three high-affinity cell surface recESCItors: TGF-? recESCItor type I (TGF-?-RI), TGF-? recESCItor type II (TGF-?-RII), and TGF-?? recESCItor type III (TGF-?-RIII). TGF-? RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-?) recESCItor subfamily. TGF-? RII has a protein kinase domain which can form a heterodimeric complex with another recESCItor protein and bind TGF-beta. This recESCItor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.