Recombinant Human TNF RII (C-mFc)
Recombinant Human Tumor Necrosis Factor RecESCItor Superfamily Member 1B is produced by our Mammalian expression system and the target gene encoding Pro24-Thr206 is expressed with a mFc tag at the C-terminus.
Description
| Reference | ESCIT211 |
|---|---|
| Size | 50ug |
| Molecular Weight | 46.44 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: Tumor necrosis factor recESCItor superfamily member 1B; TNFRSF1B; Tumor necrosis factor recESCItor 2; TNF-R2; TNF-RII; Tumor necrosis factor recESCItor type II; p75; p80 TNF-alpha recESCItor; CD120b
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: Tumor necrosis factor recESCItor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor recESCItor superfamily. Human TNF RII contains four cysteinerich rESCIeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF? and Lymphotoxin?/TNF??soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF recESCItors.