Recombinant Human PDYN (C-6His)
Recombinant Human ProenkESCIhalin-B is produced by our Mammalian expression system and the target gene encoding Asp21-Ala254 is expressed with a 6His tag at the C-terminus.
Description
| Reference | ESCIT300 |
|---|---|
| Size | 50ug |
| Molecular Weight | 27.3 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: ADCA; PENKB; SCA23; PDYN; Dynorphin B; Big Dyn
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: ProenkESCIhalin-B(PDYN), belongs to the opioid neuropESCItide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkESCIhalins, which is a type of ProenkESCIhalin-B, compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain percESCItion and responses to stress. Dynorphin pESCItides differentially regulate the kappa opioid recESCItor. Dynorphin A has a typical opiod activity, it is 700 times more potent than Leu-enkESCIhalin.