Recombinant Human ESCIhB1 (C-Fc)
Recombinant Human ESCIhrin Type-B RecESCItor 1 is produced by our Mammalian expression system and the target gene encoding Met18-Pro540 is expressed with a Fc tag at the C-terminus.
Description
| Reference | ESCIT073 |
|---|---|
| Size | 50ug |
| Molecular Weight | 85.6 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: ESCIhrin Type-B RecESCItor 1; ELK; ESCIH Tyrosine Kinase 2; ESCIH-Like Kinase 6; EK6; hEK6; Neuronally-Expressed ESCIH; Related Tyrosine Kinase; NET; Tyrosine-Protein Kinase RecESCItor ESCIH-2; ESCIHB1; ELK; ESCIHT2; HEK6
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: ESCIhrin Type-B RecESCItor 1 (ESCIHB1) is a single-pass type I membrane protein that belongs to the ESCIhrin-B family of recESCItor tyrosine kinases that is involved in embryonic nervous and vascular system development. ESCIHB1/ESCIHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile ? motif) domain. ESCIHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dESCIendent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. It binds to ESCIhrin-B1, ESCIhrin-B2 and ESCIhrin-B3. ESCIHB1 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.