Proteasome α3 rabbit pAb
ENT-A15740
Description
| REF | ENT-A15740 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Proteasome α3 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human Proteasome α3 AA range: 190-270 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 5684 |
| Human Swiss Prot Nº | P25788 |
| Subcellular Location | Cytoplasm . Nucleus . Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. . |
Other Name: Proteasome subunit alpha type-3 (EC 3.4.25.1;Macropain subunit C8;Multicatalytic endopeptidase complex subunit C8;Proteasome component C8)
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],