POT1 rabbit pAb
ENT-A3516
Description
| REF | ENT-A3516 |
|---|---|
| Category | Antibody Polyclonal |
| Description | POT1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Monkey |
| Reactivity | Human;Monkey |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 70kD |
| Human Gene ID | 25913 |
| Human Swiss Prot Nº | Q9NUX5 |
| Subcellular Location | Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA. |
Other Name: POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
Background: protection of telomeres 1(POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],