PLCγ2 (phospho-Tyr759) rabbit pAb
ENT-A12371
Description
| REF | ENT-A12371 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PLCγ2 (phospho-Tyr759) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IF;ELISA;IHC |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200 |
| Immunogen | Synthesized phosho peptide around human PLCγ2 (Tyr759) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 148kD |
| Human Gene ID | 5336 |
| Human Swiss Prot Nº | P16885 |
| Subcellular Location | intracellular,cytosol,plasma membrane,extracellular exosome, |
Other Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],