PI 3-kinase p85α (phospho Tyr607) rabbit pAb
ENT-A2000
Description
| REF | ENT-A2000 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PI 3-kinase p85α (phospho Tyr607) rabbit pAb |
| Source | Rabbit |
| Applications | IF;WB;IHC;ELISA |
| Reactivity | Human;Mouse;Rat;Chicken(testedbyourcustomer） |
| Reactivity | Human;Mouse;Rat;Chicken(testedbyourcustomer） |
| Dilution | IF: 1:50-200 Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PI3-kinase p85-alpha around the phosphorylation site of Tyr607. AA range:573-622 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 80kD |
| Human Gene ID | 5295 |
| Human Swiss Prot Nº | P27986 |
| Subcellular Location | nucleus,cytoplasm,cis-Golgi network,cytosol,plasma membrane,cell-cell junction,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,membrane,perinuclear endoplasmic reticulum membrane, |
Other Name: PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alph
Background: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],