PHLP1 rabbit pAb
ENT-A11157
Description
| REF | ENT-A11157 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PHLP1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 188kD |
| Human Gene ID | 23239 |
| Human Swiss Prot Nº | O60346 |
| Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; [Isoform 2]: Cell membrane . |
Other Name:
Background: PH domain and leucine rich repeat protein phosphatase 1(PHLPP1) Homo sapiens This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011],