PEN2 rabbit pAb
ENT-A12417
Description
| REF | ENT-A12417 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PEN2 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human; Mouse;Rat |
| Reactivity | Human; Mouse;Rat |
| Dilution | IHC-p 1：50-200 |
| Immunogen | Synthesized peptide derived from human PEN2 AA range: 51-101 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 55851 |
| Human Swiss Prot Nº | Q9NZ42 |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. . |
Other Name:
Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer’s disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],