PARP-1 rabbit pAb
ENT-A12474
Description
| REF | ENT-A12474 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PARP-1 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;WB |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | IHC-p 1:50-200, WB 1:500-2000 |
| Immunogen | Synthesized peptide derived from human PARP-1 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 113kD |
| Human Gene ID | 142 |
| Human Swiss Prot Nº | P09874 |
| Subcellular Location | Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. . |
Other Name: Poly [ADP-ribose] polymerase 1 (PARP-1;EC 2.4.2.30;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD(+) ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1)
Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],