NLK rabbit pAb
ENT-A9491
Description
| REF | ENT-A9491 |
|---|---|
| Category | Antibody Polyclonal |
| Description | NLK rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Rat;Mouse |
| Reactivity | Human;Rat;Mouse |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 230-310 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 57kD |
| Human Gene ID | 51701 |
| Human Swiss Prot Nº | Q9UBE8 |
| Subcellular Location | Nucleus . Cytoplasm . Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). . |
Other Name:
Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin.,function:Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.,PTM:Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly nuclear. A smaller fraction is cytoplasmic.,subunit:Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB.,