NF-L rabbit pAb
ENT-A4032
Description
| REF | ENT-A4032 |
|---|---|
| Category | Antibody Polyclonal |
| Description | NF-L rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. IHC-p: 1:100-300 ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from the C-terminal region of human NF-L. |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 61kD |
| Human Gene ID | 4747 |
| Human Swiss Prot Nº | P07196 |
| Subcellular Location | Cell projection, axon . Cytoplasm, cytoskeleton . |
Other Name: NEFL; NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein
Background: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],