NBR1 (7C3) Mouse mAb
ENT-A1619
Description
| Ref | ENT-A1619 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | 1A13B, MIG19, Nbr1 |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human, Mouse, Rat |
| Dilution | IHC 1:100-200 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 120kDa |
| Human Gene ID | 4077 |
| Human Swiss Prot No | Q14596 |
| Subcellular Location | Cytoplasm, Cytoplasmic vesicle, Lysosome |
Background: NBR1 protein is known for its encoding gene proximity to the BRCA1 tumor suppressor gene. N-terminal Phox and Bem1p (PB1) domains of NBR1 mediate its interaction with muscle specific titin kinase and scaffolding protein p62. NBR1 plays a role in autophagy by facilitating the autophagosomal degradation of ubiquitinated proteins independently and also in concert with p62.