Myosin Heavy Chain Mouse mAb
ENT-A1437
Description
| Ref | ENT-A1437 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | Bsh, CG17927, Dm II, DmelCG17927, DmMHC, DROMHC, DroMII, FBgn0002741, Ifm(2)2, l(2)36Ae, l(2)k10423, l(2)M66, Mhc, Mhc36B, mMHC, MRP, Myo, Myosin heavy chain, Nup, Sht, sMHC, Stp |
| Application | IHC, IF |
| Source | Mouse |
| Reactivity | Human, Mouse, Rat, Fruit Fly, Nematode |
| Dilution | IHC 1:200 IF 1:100 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 220kDa |
| Human Gene ID | 4619 |
| Human Swiss Prot No | P12882 |
| Subcellular Location | Cytoplasm, Thick filament |
Background: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. These two isoforms are expressed in different amounts in the human heart. During normal physiology, beta-cardiac MHC is the predominant form, with the alpha-isoform contributing around only 7% of the total MHC. Mutations of the MHC genes are associated with several different dilated and hypertrophic cardiomyopathies.