MLKL (phospho Ser358) rabbit pAb
ENT-A12734
Description
| REF | ENT-A12734 |
|---|---|
| Category | Antibody Polyclonal |
| Description | MLKL (phospho Ser358) rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;WB |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000 |
| Immunogen | Synthesized peptide derived from human MLKL (phospho S358) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 55kD |
| Human Gene ID | 197259 |
| Human Swiss Prot Nº | Q8NB16 |
| Subcellular Location | Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). . |
Other Name: Mixed lineage kinase domain-like protein
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],