MACC1 rabbit pAb
ENT-A4201
Description
| REF | ENT-A4201 |
|---|---|
| Category | Antibody Polyclonal |
| Description | MACC1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 97kD |
| Human Gene ID | 346389 |
| Human Swiss Prot Nº | Q6ZN28 |
| Subcellular Location | Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors. |
Other Name: MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
Background: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],