ITGA2B (heavy chain, Cleaved-Leu32) rabbit pAb
ENT-A15540
Description
| REF | ENT-A15540 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ITGA2B (heavy chain, Cleaved-Leu32) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human ITGA2B (heavy chain, Cleaved-Leu32) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 95 110kD |
| Human Gene ID | 3674 |
| Human Swiss Prot Nº | P08514 |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
Other Name: Integrin alpha-IIb (GPalpha IIb;GPIIb;Platelet membrane glycoprotein IIb;CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
Background: This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016],