IL-1F7 rabbit pAb
ENT-A8076
Description
| REF | ENT-A8076 |
|---|---|
| Category | Antibody Polyclonal |
| Description | IL-1F7 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen | Synthetic peptide from human protein at AA range: 101-150 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 27178 |
| Human Swiss Prot Nº | Q9NZH6 |
| Subcellular Location | Cytoplasm, cytosol . Nucleus . Secreted . Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). . |
Other Name: Interleukin-37 (FIL1 zeta;IL-1X;Interleukin-1 family member 7;IL-1F7;Interleukin-1 homolog 4;IL-1H;IL-1H4;Interleukin-1 zeta;IL-1 zeta;Interleukin-1-related protein;IL-1RP1;Interleukin-23;IL-37)
Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],