IGF-I Receptor β (phospho-Tyr1316) rabbit pAb
ENT-A13087
Description
| REF | ENT-A13087 |
|---|---|
| Category | Antibody Polyclonal |
| Description | IGF-I Receptor β (phospho-Tyr1316) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human IGF-I Receptor β (Tyr1316) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | pro: 155kD, recetor beta: 95kD |
| Human Gene ID | 3480 |
| Human Swiss Prot Nº | P08069 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . |
Other Name: Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],