IDE/Insulin Degrading Enzyme Mouse mAb
ENT-A1462
Description
| Ref | ENT-A1462 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN |
| Application | WB, IHC |
| Source | Mouse |
| Reactivity | Human |
| Dilution | WB 1:1,000 IHC 1:200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 118kDa |
| Human Gene ID | 3416 |
| Human Swiss Prot No | P14735 |
| Subcellular Location | Cell membrane, Cytoplasm, Membrane, Secreted |
Background: Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently.