HLA-DOβ rabbit pAb
ENT-A2912
Description
| REF | ENT-A2912 |
|---|---|
| Category | Antibody Polyclonal |
| Description | HLA-DOβ rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 30kD |
| Human Gene ID | 3112 |
| Human Swiss Prot Nº | P13765 |
| Subcellular Location | Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. |
Other Name: HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
Background: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],