HLA-DMβ rabbit pAb
ENT-A8142
Description
| REF | ENT-A8142 |
|---|---|
| Category | Antibody Polyclonal |
| Description | HLA-DMβ rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;ELISA |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen | Synthetic peptide from human protein at AA range: 40-100 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 3109 |
| Human Swiss Prot Nº | P28068 |
| Subcellular Location | Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Localizes to late endocytic compartment. Associates with lysosome membranes. |
Other Name: HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB;Really interesting new gene 7 protein)
Background: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],