GFAP Mouse mAb
ENT-A1438
Description
| Ref | ENT-A1438 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | Glial Fibrillary Acidic Protein ;Intermediate Filament Protein |
| Application | WB, IHC |
| Source | Mouse |
| Reactivity | Rat, Mouse |
| Dilution | WB 1:2,000-5,000 IHC 1:200-500 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 45kDa |
| Human Gene ID | 2670 |
| Human Swiss Prot No | P14136 |
| Subcellular Location | Cytoplasm. Associated with intermediate filaments |
Background: GFAP is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.