Frizzled-7 rabbit pAb
ENT-A2767
Description
| REF | ENT-A2767 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Frizzled-7 rabbit pAb |
| Source | Rabbit |
| Applications | WB;Flow Cyt;IF;ELISA |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:500-2000;Flow Cyt 1:50-200;IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 64kD |
| Human Gene ID | 8324 |
| Human Swiss Prot Nº | O75084 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. . |
Other Name: FZD7; Frizzled-7; Fz-7; hFz7; FzE3
Background: frizzled class receptor 7(FZD7) Homo sapiens Members of the ‘frizzled’ gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],