FAT1 rabbit pAb
ENT-A8442
Description
| REF | ENT-A8442 |
|---|---|
| Category | Antibody Polyclonal |
| Description | FAT1 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1140-1220 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 504kD |
| Human Gene ID | 2195 |
| Human Swiss Prot Nº | Q14517 |
| Subcellular Location | [Protocadherin Fat 1]: Cell membrane ; Single-pass type I membrane protein .; [Protocadherin Fat 1, nuclear form]: Nucleus . |
Other Name:
Background: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008],