EGFR (Phospho-Tyr998) rabbit pAb
ENT-A13551
Description
| REF | ENT-A13551 |
|---|---|
| Category | Antibody Polyclonal |
| Description | EGFR (Phospho-Tyr998) rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;WB |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | IHC-p 1:50-200, WB 1:500-2000 |
| Immunogen | Synthesized peptide derived from human EGFR (Phospho-Tyr998) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 175kD |
| Human Gene ID | 1956 |
| Human Swiss Prot Nº | P00533 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted. |
Other Name: Epidermal growth factor receptor (EC 2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1)
Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],