DR6 (phospho-Ser562) rabbit pAb
ENT-A13605
Description
| REF | ENT-A13605 |
|---|---|
| Category | Antibody Polyclonal |
| Description | DR6 (phospho-Ser562) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human DR6 (Ser562) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 72kD |
| Human Gene ID | 27242 |
| Human Swiss Prot Nº | O75509 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . |
Other Name: Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Background: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],