DNA pol β (Acetyl Lys72) rabbit pAb
ENT-A15652
Description
| REF | ENT-A15652 |
|---|---|
| Category | Antibody Polyclonal |
| Description | DNA pol β (Acetyl Lys72) rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human DNA pol β (Acetyl Lys72) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 38kD |
| Human Gene ID | 5423 |
| Human Swiss Prot Nº | P06746 |
| Subcellular Location | Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage. |
Other Name: DNA polymerase beta (EC 2.7.7.7;EC 4.2.99.-)
Background: catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts “gap-filling” DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5′-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,