DLG4 rabbit pAb
ENT-A15884
Description
| REF | ENT-A15884 |
|---|---|
| Category | Antibody Polyclonal |
| Description | DLG4 rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human DLG4 AA range: 530-610 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 1742 |
| Human Swiss Prot Nº | P78352 |
| Subcellular Location | Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cytoplasm . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cell junction, synapse, presynapse . High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. . |
Other Name: Disks large homolog 4 (Postsynaptic density protein 95;PSD-95;Synapse-associated protein 90;SAP-90;SAP90)
Background: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],