DEN1B rabbit pAb
ENT-A13661
Description
| REF | ENT-A13661 |
|---|---|
| Category | Antibody Polyclonal |
| Description | DEN1B rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human; Mouse |
| Reactivity | Human; Mouse |
| Dilution | WB 1：500-2000 |
| Immunogen | Synthesized peptide derived from human DEN1B AA range: 325-375 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 163486 |
| Human Swiss Prot Nº | Q6P3S1 |
| Subcellular Location | Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle . |
Other Name:
Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],