Cystatin C (7F11) Mouse mAb
ENT-A1580
Description
| Ref | ENT-A1580 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | AD8, Cystatin3, Gamma trace, HCCAA |
| Application | WB, IHC, ELISA |
| Source | Mouse |
| Reactivity | Human |
| Dilution | WB 1:1,000-2,000 IHC 1:100-200 ELISA 1:10,000-20,000 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 14kDa |
| Human Gene ID | 1471 |
| Human Swiss Prot No | P01034 |
| Subcellular Location | Secreted |
Background: Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.