CTIP (Phospho Ser327) rabbit pAb
ENT-A15671
Description
| REF | ENT-A15671 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CTIP (Phospho Ser327) rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human CTIP (Phospho Ser327) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 100kD |
| Human Gene ID | 5932 |
| Human Swiss Prot Nº | Q99708 |
| Subcellular Location | Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). . |
Other Name: DNA endonuclease RBBP8 (EC 3.1.-.-;CtBP-interacting protein;CtIP;Retinoblastoma-binding protein 8;RBBP-8;Retinoblastoma-interacting protein and myosin-like;RIM;Sporulation in the absence of SPO11 protein 2 homolog;SAE2)
Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],