Crystallin-αC rabbit pAb
ENT-A16020
Description
| REF | ENT-A16020 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Crystallin-αC rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | WB: 1:500-1000 |
| Immunogen | Recombinant Protein of Crystallin-αC |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | |
| Observed Band KD | 22kD |
| Human Gene ID | 26353 |
| Human Swiss Prot Nº | Q9UJY1 |
| Subcellular Location | Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock. |
Other Name: HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
Background: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],