Connexin-26 rabbit pAb
ENT-A2466
Description
| REF | ENT-A2466 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Connexin-26 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Connexin-26. AA range:45-94 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 26kD |
| Human Gene ID | 2706 |
| Human Swiss Prot Nº | P29033 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Colocalizes with GJB4 at gap junction plaques in the cochlea. . |
Other Name: GJB2; Gap junction beta-2 protein; Connexin-26; Cx26
Background: This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008],