Collagen II (8F6) Mouse mAb
ENT-A1618
Description
| Ref | ENT-A1618 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | Alpha 1 type II collagen , AOM, Col2a1 antibody |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human, Mouse, Rat |
| Dilution | IHC 1:100-200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 142kDa |
| Human Gene ID | 1280 |
| Human Swiss Prot No | P02458 |
| Subcellular Location | Secreted,extracellular space,extracellular matrix |
Background: Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice and higher primates which can resemble rheumatoid arthritis and relapsing polychrondritis.